Dr. Frank Antonawich

Publications
Abstracts
Antonawich, F.J. (2018) Neuro-Metabolic Protection and Support for Mitochondrial Damage and Dysfunction. Advanced Applications in Medical Practice (AAMP), Scottsdale, AZ.
Antonawich, F.J. (2017) Enhancing Cellular Respiration with Lipoic Acid Mineral Complex: Poly MVA. Tripping Over the Truth Conference (Invited Speaker), Baltimore, MD.
Antonawich, F.J. (2017) Targeting Cancer Metabolic Dysfunction. Advanced Applications in Medical Practice (AAMP), Portland, OR.
Szema, A.M., Lin, D., Li, J.C., Razi, R., Qamar, N. Levine, L., Zimmerman, T. Hamidi, S.A., Schmidt, M., Golightly, M.G., Rueb, T., Harrington, Garnett, M., Miller, E.G., Antonawich, F. (2017) Rux Largely Restores Lungs in Iraq PM-Exposed Mice, Up-Regulating Regulatory T Cells (Tregs). American Journal of Respiratory and Critical Care Medicine 195: A3879.
Antonawich, F.J. (2016) Poly MVA: A Strategy to Address Neoplastic Metabolic Anaplasia. International Organization of Integrative Medicine Conference, San Diego, CA.
Antonawich, F.J. (2015) Palladium Lipoic Acid Complex: A Non-Toxic Radiation Protection and Mitigation Agent. Conference on Normal Tissue Radiation Effects and Countermeasures (CONTREC), Morrilton, AR.
Antonawich, F.J. (2015) Lipoic Acid Mineral Complex: A METABOLICALLY-TARGETED ADJUNCT FOR CANCER THERAPY International Organization of Integrative Cancer Physicians Conference, Reno, NV.
Antonawich, F.J. (2014) Poly-MVA: A Metabolically-Targeted Integrative Agent. International Organization of Integrative Cancer Physicians Conference, Reno, NV.
Antonawich, F.J. (2012) Poly MVA: An Effective Approach to Treating Cancer, Stroke & Increasing Quality of Life. 40th Cancer Control Society Convention, Los Angeles, CA.
Antonawich, F.J., Garnett, M. (2012) Palladium Lipoic Acid Complex: A Non-Toxic Metabolically Targeted Chemotherapy Molecule. American Association of Naturopathic Physicians, Bellevue, WA.
Antonawich, F.J. (2011) Palladium Lipoic Acid Complex: A Metabolically Targeted Cancer Therapy. Advances in Integrative Medicine Conference. Orlando, FL.
Blick, G. and Antonawich, F.J. (2010) Combating HIV-Associated Fatigue using a Palladium Alpha-Lipoic Acid (PdLA) Complex. Conference on Retroviruses and Opportunistic Infections (CROI). San Francisco, CA.
Krishnan, C.V., Garnett, M., Antonawich, F. (2010) Palladium α-Lipoic Acid Complex: A Multispectrum Nontoxic Chemotherapeutic Agent. World Conference on Cancer 2010 Kottayam, Kerala, India.
Blick, G. and Antonawich, F.J. (2010) Evaluation of a Palladium Alpha-Lipoic Acid (PdLA) Complex in HIV/AIDS Patients with Chronic Fatigue. XVIII International AIDS Conference Vienna, Austria.
Antonawich, F.J. (2008) Providing Integrative Energy in Cancer & Ischemia: Metabolically Targeted Therapy. XVI International Congress on Anti-Aging Medicine,Las Vegas, NV.
Antonawich, F.J. (2008) Metabolically Targeted Therapy in Disease. American Association of Critical Care Nurses Conference, Long Island, NY.
Antonawich, F.J. (2007) The Metabolic Role of Palladium Lipoic Acid Complex: Mitochondrial Health and Subsequent Regulation of Cellular Death, American College for Advancement in Medicine, Phoenix AZ.
Antonawich, F.J. (2006) Palladium Lipoic Complex: The Role of this Selective Metabolic Modulator in Cancer, XIV International Congress on Anti-Aging Medicine, Las Vegas, NV.
Antonawich, F.J. (2006) Palladium Lipoic Complex Utilizes Energy to Modulate Programmed Cell Death. XIV International Congress on Anti-Aging Medicine , Chicago, IL.
Antonawich, F.J. (2006) Palladium Lipoic Complex (Poly MVA) Regulation of Cell Death. World Organization of Natural Medicine Conference , Nassau, Bahamas.
Antonawich, F.J. (2006) A Combination of Antioxidant Activity & an Energy Source is an Effective Strategy in the Regulation of Degenerative Diseases. CAM East , New York, NY.
Antonawich, F.J. (2006) Palladium Lipoic Complex: Regulation of Cancer and Stroke Cell Death. XIII International Congress on Anti-Aging Medicine , Orlando, FL.
Antonawich, F.J. (2005) Poly MVA Induced Regulation of Cell Death in Cancer and Stroke. XII International Congress on Anti-Aging Medicine , Chicago, IL.
Antonawich, F.J. (2005) A Combination of Antioxidant Activity and an Alternative Energy Source is an Effective Anti-Ischemic Strategy, XIII International Congress on Anti-Aging Medicine , Las Vegas, NV.
Antonawich, F.J. (2005) Lipoic Acid Palladium Complex: The Use of Energy in the Regulation of Cell Death in Cancer and Stroke. PRE-CONFERENCE, XIII International Congress on Anti-Aging Medicine , Las Vegas, NV.
Antonawich, F.J. (2005) Poly MVA Provides Energy to Alter Cell Death. Nevada Homeopathic and Integrative Medicine Conference, Las Vegas, NV.
Antonawich, F.J. (2005) Poly MVA: Modulates Cancer Cell Death. 33rd Cancer Control Society Convention, Los Angeles, CA.
Antonawich, F.J. (2005) Poly MVA Induced Regulation of Cell Death in Cancer and Stroke. XII International Congress on Anti-Aging Medicine , Chicago, IL.
Antonawich, F.J. (2005) Palladium Lipoic Complexes: New Science Shows How Cancer, Stroke and Aging Are Impacted and Influenced By Cellular Energy Production. International Natural Foods & Health Expo, Cleveland Health Museum, Cleveland, OH.
Antonawich, F.J. (2004) Poly MVA: Mechanism of Apoptotic Action. Meeting- Department of Oncology, Florida Hospital, Orlando, FL.
Antonawich, F.J. (2004) Effective Regulation of Cell Death in Cancer and Stroke: Palladium Lipoic Compounds. Meeting of the International College of Integrative Medicine (ICIM), Atlanta, GA.
Antonawich, F.J. (2004) Poly MVA: Cellular Energy Production Utilized to Impact Cancer, Stroke and Aging. Conference of the American Association of Naturopathic Physicians (AANP), Seattle, WA.
Antonawich, F.J., Forsythe, J.W.M. (2004) The Effects of the Palladium Lipoic Acid Compound, Poly MVA, in Cancer and Stroke. XII International Congress on Anti-Aging Medicine- A4M, Las Vegas, NV.
Antonawich, F.J. (2004) Modulation of Ischemic and Cancer Cell Death Using Poly MVA
American College for Advancement in Medicine (ACAM) Conference, San Diego, CA.
Antonawich, F.J. (2004) Palladium Lipoic Acid Compound, Poly MVA, Modulation of Ischemic Cell Death. XI International Congress on Anti-Aging Medicine – A4M, Chicago, IL.
Antonawich, F.J., Welicky,L.M., Fiore, S.M. (2004) Regulation of Ischemic Cell Death using the Lipoic Acid Palladium Complex, Poly MVA. Society for Neuroscience, Abstract # 379.3.
Antonawich, F.J. and Welicky, L.M. (2003) Neuroprotective Effects of the Lipoic Acid Palladium Complexes in Stroke and Cerebral Ischemia. New Dimensions in Health & Medicine Conference, Abstract, Phoenix, AZ.
Antonawich, F.J., Fiore, S.M. (2001) Alterations in the bcl-2 family of apoptotic regulatory proteins in huntington’s disease transgenic mice. Society for Neuroscience, Abstract #432.12.
Antonawich, F.J., Fiore, S.M., Davis, J.N. (2000) Glucocorticoid receptor expression and response in hippocampal progenitor cells. Society for Neuroscience, Abstract #24.2.
Davis, J.N., Welicky,L.M., Antonawich, F.J., (2000) Notch-3 expression is decreased in gerbil hippocampus after transient global ischemia. Society for Neuroscience, Abstract #281.7.
Parker, C.P., Fiore, S.M., Antonawich, F.J. (2000) Modulation of apoptotic regulatory proteins and ear activation of cytochrome c in rats following systemic administration of 3-nitropropionic acid (3-NP). Society for Neuroscience, Abstract #579.7.
Antonawich, F.J., Towner, M., Calandrella,C., Fiore, S.M., Davis, J.N. (1999) Glucocorticoid and ACTH modulation of hippocampal progenitor cells. Society for Neuroscience, Abstract #738.23, 25:1852.
Antonawich, F.J., Fiore, S.M. Davis, J.N. (1998) The effects of a Lipoic Acid / Palladium complex on hippocampal progenitor cells. Society for Neuroscience, Abstract #857.10, 24:2161.
Antonawich, F.J., Reed, M., Tegtmeyer, P., Scheffer, S.R., Davis, J.N. (1998) Neuronal gene delivery of a truncated p53 fragment using a herpes simplex virus (HSV). American Society of Gene Therapy, Seattle, WA.
Antonawich, F.J., Federoff, H., Reed, J.C., Krajewski, S., Davis, J.N. (1996) Ischemic CA1 hippocampal neurons express bax and can be rescued by bcl-2 induction with a herpes simplex (HSV) amplicon. Society for Neuroscience, Washington D.C.
Antonawich, F.J., Melton, C.S., Wu, P., Davis, J.N. (1996) Nesting behavior as an indicator of hippocampal ischemic damage. Society for Neuroscience, Washington, D.C.
Antonawich, F.J., Wu, P., Davis, J.N. (1995) Reduction of ischemic CA1 hippocampal damage in gerbils following Org 2766 treatment . Society for Neuroscience, Abstract #94.13, 21:212.
Antonawich, F.J., Wu, P., Davis, J.N. (1995) RU 38486 and an ACTH 4-9 analog regulate the rate of ischemic CA1 pyramidal cell death. National Association of EMS Physicians: Cerebral Resusitation, Naples, Florida.
Antonawich, F.J., Wu, P., Davis, J.N. (1995) Regulation of ischemic hippocampal damage following ACTH treatment. American Heart Association: Stroke Meeting, Charleston, South Carolina.
Antonawich, F.J., Azmitia, E.C. Strand, F.L. (1994) Specificity vs redundancy of melanocortins in nerve regeneration. Winter Neuropeptide Conference, Breckenridge, Colorado.
Antonawich, F.J., Azmitia, E.C., Strand, F.L. (1993) The neurotrophic effects of Org 2766 (an ACTH 4-9 analog) after nigrostriatal lesioning. Summer Neuropeptide Conference, Martha’s Vineyard, Massachusettes.
Antonawich, F.J., Akbari, H.M., Azmitia, E.C., Strand, F.L. (1992) The protective effects of an ACTH 4-9 analog, Org 2766, on 6-OHDA lesioning of the substantia nigra. Society for Neuroscience, Abstract #271.11, 18:629.
Strand, F.L., Zuccarelli, L.A., Williams, K.A., Lee, T.S., Lee, S.J., Antonawich, F.J., Alves, S.E. (1992) Melanotropins as growth factors. Conference of the New York Academy of Sciences, Rouen, Normandy, France.
Strand, F.L., Zuccarelli, L.A., Lee, T.S., Lee, S.J., Antonawich, F.J. (1992) Effects of ACTH neuropeptides on developing and regenerating motor systems. International Meeting on Strategies for Studying CNS Active Compounds: Models, Screens and Clinical Syndromes, Madrid, Spain.
Alves, S.E., Akbari, H.M., Antonawich, F.J., Azmitia, E.C., Strand, F.L. (1991) Effects of postnatal administration of ACTH and nicotine on reproductive parameters of the female rat. Society for Neuroscience, Abstract #634.6, 17:1594.
Antonawich, F.J., Strand, F.L. (1990) Alterations in rotational and open-field behavior following 6-OHDA lesioning of the substantia nigra and administration of Org 2766. Society for Neuroscience, Abstract #479.12, 16:1157.

Books
Krishnan, C.V., Garnett, M., Antonawich, F. (2011) Multispectrum Nontoxic Chemotherapeutic Agents. Integrative Cancer Therapies. (chapter).
Antonawich, F.J. (1994) The acute neurotrophic effects of an ACTH 4-9 analog, Org 2766, following nigrostriatal 6-OHDA lesioning. F.J. Antonawich (Ed.), New York University, Ph.D. thesis.
Antonawich, F.J., Alves, S.E., Lee, S.J., Williams, K.A., Tolvo, A., Strand, F.L. (1993) Experiments in general and human physiology: A laboratory manual. L.A. Zuccarelli, F.J. Antonawich, F.L. Strand (Eds.), LPNE Publications, New York, N.Y.

Articles
Lin, D., Li, J., Razi,R., Qamar, N., Levine, L., Zimmerman, T., Hamidi, S.A., Schmidt, M., Golightly, M.G., Rueb, T., Harrington, A., Garnett, M., Antonawich F., McClain, S., Cox, C., Huang, P.H., Szema, A.M. (2018) RUX Large Restores Lungs in Ira PM-exposed Mice, Up-Regulating Regulatory T-cells (Tregs). Experimental Lung Research 0: 1-14; https://doi.org/10.1080/01902148.2018.1459957.
Antonawich F, Veena RK, Ajith TA, Janardhanan KK. (2017) Preparatory Liquid Blend, Poly-MVA and Rejeneril-A Protect the Radiation-Induced DNA Damage and Lesions of Ileum. J Basic Clin Pharma 8: S054-S059.
Sridharan, V., Seawright, J., Antonawich, F.J., Garnett, M., Cao, M., Singh, P., Boerma, M. (2017) Late Administration of a Palladium Lipoic Acid Complex (Poly-MVA) Modifies Cardiac Mitochondria but not Functional or Structural Manifestations of Radiation-Induced Heart Disease in a Rat Model. Journal of Radiation Research 187(3): 361-366.
Veena RK, Ajith TA, Janardhanan KK, Antonawich F. (2016) Antitumor Effects of Palladium--Lipoic Acid Complex Formulation as an Adjunct in Radiotherapy. Journal of Environmental Pathology, Toxicology and Oncology, 35(4):99-107.
Veena RK, Ajith TA, Janardhanan KK, Antonawich F. (2015) Poly-MVA attenuates 7,12- dimethylbenz [] anthracene initiated and croton oil promoted skin papilloma formation on mice skin. Journal of Experimental Therapeutics and Oncology, 11(2): 125-132.
Anthony M. Szema, A.M., Garnett, M., Antonawich, F., Zimmerman, T., Levine, L., Hamidi, S.A. (2014) RUX, a novel anti-inflammatory drug, suppresses CCL12 gene expression and increases lung compliance in VIP KO Mice. Laboratory Investigations.
Ajith TA, Nima N, Veena RK, Janardhanan KK, Antonawich F. (2014) Effect of Palladium α-Lipoic Acid Complex on Energy in the Brain Mitochondria of Aged Rats. Altern Ther Health Med. 20(3):27-35.
Krishnan, C.V., Garnett, M., Antonawich, F. (2012) Free Radicals in Neurodegenerative Diseases: Modulation by Palladium α-Lipoic Acid Complex. Chapter 4: Neurodegenerative Diseases – Processes, Prevention, Protection and Monitoring, edited by Raymond Chuen-Chung Chang, ISBN 978-953-307-485, p. 89-126.
Krishnan, C.V., Garnett, M., Antonawich, F. (2011) Mitochondrial Dysfunction and Cancer: Modulation by Palladium α-Lipoic Acid Complex. Nanomedicine and Cancer Therapies, edited by Mathew Sebastian, Neethu Ninan, Eldho Elias, Apple Academic Press. ISBN 9781926895185, Ch 7.
Antonawich, F.J. (2009) Providing Integrative Energy in Cancer: Metabolically Targeted Therapy. Anti-Aging Therapeutics, (Volume XI):13- 19.
Antonawich, F.J. (2008) Utilizing Integrative Energy in Cancer & Ischemia as Metabolically Targeted Therapy. Anti-Aging News, (Winter edition):48-51.
Antonawich, F.J., Valane, P.D., Valane, A.A., Welicky, L.M. (2007) Poly MVA Attenuates Hypoxia Inducible Factor (HIF-1) Expression in Glioblastoma Multiforme In Vitro.. (submitted).
Lieberman, S. and Antonawich, F.J. (2007) Poly-MVA in an Integrative Approach to the Treatment of Multiple Myeloma: A Case Report. Townsend Letter, August/September: 107-111.
Antonawich, F.J. and Valane,P.D. (2007) Palladium Lipoic Acid Complex (PdLA):“Metabolic Management for Anti-Aging”, Anti-Aging Therapeutics, (9): 13-16.
Lieberman, S. and Antonawich, F.J. (2006) Case Report: A Complementary Dietary Supplementation with Chemotherapy in Multiple Myeloma Management. Altern Med Rev. 11[4].
Antonawich, F.J. (2006) POLY- MVA “A Selective Metabolic Modulator” ACAM.
Antonawich, F.J. (2005) Palladium Lipoic Complex: “Energy to Get the Job Done”
Anti-Aging Therapeutics, (8):5-8.
Cancer Monthly – Nutritional Supplement Reported to Help Cancer Patients Undergoing First Clinical Trial: One Patient’s Experience: Mark Olsztyn; Interim Results From The First Clinical Study:James William Forsythe M.D., H.M.D; Studying The Biological Mechanisms: Francis J. Antonawich, Ph.D.; Cancer Wire (online)- Cancer Monthly, May 2005.
Antonawich, F.J., Welicky, L.M. (2005) Ischemic Neuroprotection following Delayed Administration of the Lipoic Acid-Palladium Complex, Poly MVA. (in preparation).
Antonawich, F.J., Fiore, S.M., Davis, J.N. (2004/2005) The effects of a Lipoic Acid / Palladium complex on hippocampal progenitor cells. Central and Peripheral Nervous System Investigational Drugs. (submitted).
Antonawich, F.J., Fiore, S.M., Davis, J.N. (2004/2005) Glucocorticoid and ACTH modulation of hippocampal stem cell proliferation and cell lineage decision. J. Neuroscience.
Antonawich, F.J., Fiore, S.M., Welicky, L.M. (2004) Regulation of Ischemic Cell Death by the Lipoic Acid-Palladium Complex, Poly MVA, in Gerbils. Experimental Neurology 189(1): 10-15.
Antonawich, F.J. (2003) The Effects of DNA Reductase on Stroke and Brain Ischemia. Garnett McKeen Medical Science Series 1(3): 1-10.
Antonawich, F.J., Said, S. (2002) Vasoactive Intestinal Peptide (VIP) attenuates the apoptotic cascade in hippocampal stem cells. Neuroscience Letters 325(3): 151-154.
Antonawich, F.J., Fiore, S.M., Parker, C.P. (2002) Modulation of apoptotic regulatory proteins and early activation of cytochrome c following systemic 3-nitropropionic acid administration. Brain Research Bulletin 57(4):647-649.
Antonawich, F.J., Reed, M., Tegtmeyer, P., Scheffer, S.R., Wu, P., Davis, J.N. (2001) Neuronal gene delivery of a truncated p53 fragment using a herpes simplex virus (HSV) amplicon. Human Gene Therapy.
Antonawich, F.J. (2000) To grow a brain cell. The Long Island Advance, March 9: 19, 30.
Antonawich, F.J. (1999) Translocation of cytochrome c following transient global ischemia in the gerbil. Neuroscience Letters 273: 1-4.
Antonawich, F.J., Federoff, H.J., Davis, J.N. (1999) Bcl-2 transduction, using a herpes simplex virus amplicon, protects hippocampal neurons from transient global ischemia. Experimental Neurology 156:130-137.
Antonawich, F.J., Miller, G., Rigsby, D., Davis, J.N. (1999) Regulation of ischemic cell death by glucocorticoids and ACTH. Neuroscience, 88(1):319-325.
Antonawich, F.J., Krajewski, S., Reed, J.C., Davis, J.N. (1998) Bcl-xl / Bax interaction following transient global ischemia. Journal of Cerebral Blood Flow and Metabolism, 18(8):882-886.
Davis, J.N., Antonawich, F.J. (1997) The role of apoptotic proteins in ischemic hippocampal damage. Annals of the New York Academy of Science, 835:309-320.
Antonawich, F.J., Melton, C.S., Wu, P., Davis, J.N. (1997) Nesting and shredding behavior as an indicator of hippocampal ischemic damage. Brain Research 764:249-252.
Strand, F.L., Williams, K.A., Alves, S.E., Antonawich, F.J., Lee T.S., Lee, S.J., Kume, J., Zuccarelli, L. (1996) Melanocortins as factors in somatic neuromuscular growth and regrowth. In: Chemical Factors in Neural Growth, Degeneration and Repair, C. Bell (Ed.), Elsevier, New York, pp. 311-337.
Antonawich, F.J., Azmitia, E.C., Kramer, H.K., Strand, F.L. (1994) Specificity vs redundancy of melanocortins in nerve regeneration. Annals of the New York Academy of Science, 739:60-73.
Antonawich, F.J. Lee, S.J. Strand, F.L. (1994) Immunohistochemical localization of ACTH 4-10 in the central nervous system following nigrostriatal injury. Annals of the New York Academy of Science, 739:123-126.
Antonawich, F.J., Azmitia, E.C., Strand, F.L. (1993) Rapid neurotrophic actions of an ACTH 4-9 analogue after nigrostriatal 6-OHDA lesioning. Peptides, 14:1317-1324.
Strand, F.L., Williams, K.A., Kume, J., Alves, S.E., Antonawich, F.J., Zuccarelli, L.A., Lee, T.S., Lee, S.J. (1993) Melanocortins as factors in somatic neuromuscular growth and regrowth. Pharmac. Ther. 62:1-27.
Strand, F.L., Zuccarelli, L.A., Kume, J., Antonawich, F.J., Lee, S.J., Lee, T.S., Williams, K.A. (1993) Non-corticotropic ACTH peptides modulate nerve development and regeneration. Reviews in the Neurosciences, 4(4):321-364.
Strand, F.L., Zuccarelli, L.A., Williams, K.A., Lee, S.J., Lee, T.S., Antonawich, F.J., Alves, S.E. (1992) Melanotropins as growth factors. Annals of the New York Academy of Sciences, 680:29-50.
Strand, F.L., Alves, S.E., Antonawich, F.J., Lee, S.J., Lee, T.S., Zuccarelli, L.A. (1992) Developing and regenerating systems as models for trophic effects of ACTH neuropeptides. In: In Strategies for Studying Brain Disorders, Vol 2: Schizophrenia, Movement Disorders and Age Related Cognitive Disorders. Palomo, T.; Archer, T.; Beninger, R. (Eds.) pp389-408.
Strand, F.L., Zuccarelli, L.A., Kume, J., Alves, S.E., Antonawich, F.J., Garret, L. (1990) Neuropeptide hormones as neurotrophic factors. Physiological Reviews, 71:1017-1046.

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